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Big Kids Die Earlier!

Big Kids Die Earlier!

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Daily brief research updates from the cognitive sciences

fat child obesity aging

Before you panic – the conclusion in the title is based on research into mice not human beings – but there could potentially be some important insights for us human beings as well.

The researchers in a collaboration between the University of Tennessee Health Science Center (UTHSC) and the École Polytechnique Fédérale de Lausanne (EPFL) were looking for genetic markers of ageing to get a clearer insight into how genes influence ageing.

This was a large-scale study: first off, they analysed the genetic data from 27,574 mice studied each of which was a full sibling, sharing half its genetic inheritance with each other mouse in the program, and each has a known lifespan, making them an ideal system to study.

They then measured the genetic makeup of over 3’000 mice all of which were also brothers or sisters, sharing genetics. They were then allowed to live their natural lives. The genetics were then compared to their lifespans. With some intriguing results.

First off, they found that much of the difference was due to sex-based differences with females having a genetic stretch on chromosome three that seems to affect lifespans (making females live longer). So far nothing new to learn here. However, they also noted when they took those that died early out of the data that some genes seem to only become active or be influential after a certain age.

This is a bit of a surprise showing that there are genetic interactions that can last over a lifetime and not just from the starting genetic makeup.
What’s more they also discovered that mice who were larger as youngsters lived shorter lives. These larger mice came from smaller litters and therefore had more access to mother milk and grew more while younger – this negatively affected lifespan. Those who came from larger litters and therefore had more competition for food and less of it, and were hence smaller, liver longer lives.

This seems a pretty big deal – if this translates to human beings which it might well, it would mean that well-fed babies, who become larger children will live shorter lives. Oh dear! It goes against some logic i.e. that having plentiful nutrition in early years is critical for lifetime health.

However, there is a big difference between under nutrition, a healthy diet, and being overfed. Maybe this is something we should pay more attention to!

Andy Habermacher

Andy Habermacher

Andy is author of leading brains Review, Neuroleadership, and multiple other books. He has been intensively involved in writing and research into neuroleadership and is considered one of Europe’s leading experts. He is also a well-known public speaker, speaking on the brain and human behaviour.

Andy is also a masters athlete (middle distance running) and competes regularly at international competitions (and holds a few national records in his age category).

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References

Maroun Bou Sleiman, Suheeta Roy, Arwen W. Gao, Marie C. Sadler, Giacomo V. G. von Alvensleben, Hao Li, Saunak Sen, David E. Harrison, James F. Nelson, Randy Strong, Richard A. Miller, Zoltán Kutalik, Robert W. Williams, Johan Auwerx.
Sex- and age-dependent genetics of longevity in a heterogeneous mouse population.
Science, 2022; 377 (6614)
DOI: 10.1126/science.abo3191

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Petting (Real) Dogs Activates the Social Brain

Petting (Real) Dogs Activates the Social Brain

Quick Hits
Daily brief research updates from the cognitive sciences

pet dog brain social

There have been lots of studies into the positive impacts of having pets around us – but this study just published looked at brain activation patterns while being with a dog, petting a dog, and with an ersatz cuddly toy lion.

The research showed that brain activation patterns were highest when petting dogs – unsurprising because this was the most interactive condition in the study. The researchers saw increased activity in the prefrontal cortex and notably in the medial prefrontal cortex which is associated with human social functions.

More surprisingly was that the cuddly toy elicited smaller responses – obvious you may think but in this study the cuddly toy was filled with a hot water bottle to be at the same temperature as a live dog and to have a similar fur texture. This was to elicit a response as close to the real thing as possible.

The response was lowest for the cuddly lion (but it did elicit a response) – possible because of the social activation as we realise it is not a live animal.

What was also interesting is that the response for petting the dog lingered on for a lot longer than any of the other conditions.

This shows that the response is not only in the moment but also has a lasting impact – that’s one reason to have pets but also an important consideration in animal assisted clinical therapy.

Andy Habermacher

Andy Habermacher

Andy is author of leading brains Review, Neuroleadership, and multiple other books. He has been intensively involved in writing and research into neuroleadership and is considered one of Europe’s leading experts. He is also a well-known public speaker, speaking on the brain and human behaviour.

Andy is also a masters athlete (middle distance running) and competes regularly at international competitions (and holds a few national records in his age category).

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References

Rahel Marti, Milena Petignat, Valentine L. Marcar, Jan Hattendorf, Martin Wolf, Margret Hund-Georgiadis, Karin Hediger. 
Effects of contact with a dog on prefrontal brain activity: A controlled trial
PLOS ONE, 2022; 17 (10): e0274833
DOI: 10.1371/journal.pone.0274833

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Metabolism Predicts Brain Health

Metabolism Predicts Brain Health

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Daily brief research updates from the cognitive sciences

ageing aging brain health

Understanding the link between dementia, brain health, and various metabolic disorders such as obesity is important and gives us important clues in guiding brain health particularly as we age.

Researchers around Amanda Lumsden of the University of South Australia have just published the results of a large-scale study and found some interesting corelations.

In this study they analysed data from 26,239 people in the UK Biobank and found that those with obesity related to liver stress, or to inflammation and kidney stress, had the most adverse brain findings. They measured associations of six diverse metabolic profiles and 39 cardiometabolic markers with MRI brain scan measures of brain volume, brain lesions, and iron accumulation, in order to identify early risk factors for dementia.

People with metabolic profiles linked to obesity were more likely to have adverse MRI profiles with:

    • lower hippocampal volume (key memory centre)
    • grey matter volumes (grey matter is related to general cognition)
    • greater burden of brain lesions
    • higher accumulation of iron

What was also surprising is the relationship to an individual’s Basal Metabolic Rate (BMR) – the BMR is how much energy your body uses when resting. This BMR is higher in those with obesity but it sems that the BMR is more influential on adverse brain markers than anything else.

So, it seems that a better measure is the BMR – this may sound surprising i.e. using more energy while resting might sound like a good fat-burning trick but it may also represent lower activity – when we ramp up activity metabolic rate increase during activity but sinks lower while resting. This may give your cells a better rest, recovery, and reset.

So, metabolism is a better predictor of brain health – and lower resting metabolism is actually related to higher general activity. Therefore, get moving to help avoid dementia and adverse brain effects!

Andy Habermacher

Andy Habermacher

Andy is author of leading brains Review, Neuroleadership, and multiple other books. He has been intensively involved in writing and research into neuroleadership and is considered one of Europe’s leading experts. He is also a well-known public speaker, speaking on the brain and human behaviour.

Andy is also a masters athlete (middle distance running) and competes regularly at international competitions (and holds a few national records in his age category).

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References

Amanda L. Lumsden, Anwar Mulugeta, Ville Petteri Mäkinen, Elina Hyppönen.
Metabolic profile based subgroups can identify differences in brain volumes and brain iron deposition.
Diabetes, Obesity and Metabolism, 2022
DOI: 10.1111/dom.14853

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How Where You Are Impacts Learning

How Where You Are Impacts Learning

Recent research has shown that the brain, or specifically the hippocampus switches between learning and remembering depending on location . . .

 

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Super Agers Have Super Neurons

Super Agers Have Super Neurons

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Daily brief research updates from the cognitive sciences

aging brain neuron

SuperAgers are those who live long, over 80, but retain their cognitive functions including a healthy functioning memory and seem to avoid neurodegenerative disorders such as Alzheimer’s.

Who wouldn’t want to know what is happening in their brains. But there are many questions. Is it their brain, or lifestyle, or the luck of the genetic lottery?

Well researchers around Caren Nassif of Northwestern University in the USA may have part of the answer. And this part lies in the size of neurons in specific regions of the brain.

To do this they analysed the donated brains of six SuperAgers, seven cognitively average elderly individuals, six young individuals, and also five individuals with early-stage Alzheimer’s.

They looked specifically at a part of the brain called the etorhinal cortex – this part is particularly important for the formation of memories which is why the researchers focused on this area. What they found is that this region had been spared from so-called tau tangles. These are clumps of protein which are markers of Alzheimer’s.

That is no surprise, but they noticed something that was surprising.

This was that the neurons in this particular region – actually in one of the six layers of brain cells in this region, layer two, to be precise – were larger.

Why is this important? Firstly, layer two of the layers of brain cells is the one that connects with other parts of the brain. But this size was not only larger than those with Alzheimer’s, or those of similar age but larger than those who were much younger also.

This suggests that this is not just healthy aging but a structural feature that seems more immune to aging. Avoiding those tau tangles is one thing because they become toxic and damage neurons is one thing but having big functional neurons is another thing.

So, all in, SuperAgers seem to have structural differences that enable their brains to remain highly functional in old age. In this particular case we now know what it is, and in what specific region. Whether this is in other region is an open question.

However, for those who aren’t SuperAgers, probably most of us,  a healthy lifestyle will still help to avoid the ravages of aging.

Andy Habermacher

Andy Habermacher

Andy is author of leading brains Review, Neuroleadership, and multiple other books. He has been intensively involved in writing and research into neuroleadership and is considered one of Europe’s leading experts. He is also a well-known public speaker, speaking on the brain and human behaviour.

Andy is also a masters athlete (middle distance running) and competes regularly at international competitions (and holds a few national records in his age category).

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References

Caren Nassif, Allegra Kawles, Ivan Ayala, et al.
Integrity of neuronal size in the entorhinal cortex is a biologic substrate of exceptional cognitive aging.
The Journal of Neuroscience, 2022; JN-RM-0679-22
DOI: 10.1523/JNEUROSCI.0679-22.2022

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