Mastodon
Vaccination to Keep Your Memory?

Vaccination to Keep Your Memory?

Quick Hits
Daily brief research updates from the cognitive sciences

brain aging memory

 

Who wouldn’t want to keep their memory when aging?!

Well, researchers have just announced some promising results in mice enabling them to keep their memories and avoid some of nasty neuro-degenerative aspects of Alzheimer’s.

What did they discover?

If you read the research and the press release, it gets technical and complicated very quickly, so let me translate this for you:

During aging we have more oxidative stress and accumulated stress over our lifetimes, this leads to various proteins, notably one called beta amyloid, building up in the brain. These clumps are resistant to removal and so end up continuing to build up over time contributing to multiple factors and particular impairing memory but in general decreased cognitive function.

The researchers around Adam Smith at the University of Kansas processed a protein from corn in the lab to produce an antigen which helps the immune system to clear out these clumped proteins in the brain. This is effectively a vaccination — mice injected with this showed greater short-term memory on lab tests (such as the clichéd maze tasks) but also on long-term memory. The markers for inflammation in the brain were also lower in blood samples.

The obvious question is would this translate to human beings? Because of the nature of the mechanism which is similar in human beings the researchers think it would but, obviously, this will need more research. But nevertheless very, very promising.

I’m waiting…

Andy Habermacher

Andy Habermacher

Andy is author of leading brains Review, Neuroleadership, and multiple other books. He has been intensively involved in writing and research into neuroleadership and is considered one of Europe’s leading experts. He is also a well-known public speaker speaking on the brain and human behaviour.

Andy is also a masters athlete (middle distance running) and competes regularly at international competitions (and holds a few national records in his age category).

twitter / LinkedIn

Reference

Adam S. Smith, Kyle R. Gossman, Benjamin Dykstra, Fei Philip Gao, Jackob Moskovitz.
Protective Effects against the Development of Alzheimer’s Disease in an Animal Model through Active Immunization with Methionine-Sulfoxide Rich Protein Antigen.
Antioxidants, 2022; 11 (4): 775
DOI: 10.3390/antiox11040775

More Quick Hits

Can Having More Children Reduce Cognitive Functioning?

Can Having More Children Reduce Cognitive Functioning?

Quick Hits
Daily brief research updates from the cognitive sciences

mother child brain

 

Having more children and late life cognition is not something that is generally researched. There are more obvious avenues such as diet, education, exercise, or socio-economic factors. That’s also why this recently published study caught my attention.

So, (to put it bluntly) can having more children make you stupider in your old age?

It seems so, but first let’s understand the limitations and why this could be the case.

First, this study, out of Columbia, analysed data from the Survey of Health, Aging and Retirement in Europe (SHARE) to look at the extent to which having three or more children, versus two children, affects late-life cognition. SHARE collects representative data from 20 European countries and in this case they were over 65 and had at least two biological children.

So, what did they find – well, yes, as I said they found that having three or more children, compared to two, reduced cognitive ability in later life – this was equivalent to 6.2 years of aging. That is a pretty large effect. Of note is that they crunched the numbers to indicate causation rather than correlation.

This effect was worst in northern European countries likely because in these countries having more children does not confer any additional resources or benefits.

What do they consider the reason for this:

    1. Having additional children incurs significant costs which can lead to a decreased quality of life or dropping below the poverty line.
    2. Having additional children lowers women’s labour market participation. This further lowers income but also working confers cognitive benefits.
    3. Having children is stressful and can have longer impacts on health and mental health

Of note is that it seems that there is no additional social benefit from having three or more children over two – social contact does not increase. These effects were much larger in the North of Europe than the South for multiple reasons such as cost of living and social structures.

The study didn’t explore other variations such as comparison to having only one child or none – they recommend this for future studies. It is also important to have this knowledge with people living ever longer and late life health and cognitive functioning becoming ever more important.

So, all in two children is enough – and that is exactly what I have. Phew!

Andy Habermacher

Andy Habermacher

Andy is author of leading brains Review, Neuroleadership, and multiple other books. He has been intensively involved in writing and research into neuroleadership and is considered one of Europe’s leading experts. He is also a well-known public speaker speaking on the brain and human behaviour.

Andy is also a masters athlete (middle distance running) and competes regularly at international competitions (and holds a few national records in his age category).

twitter / LinkedIn

Reference

Eric Bonsang, Vegard Skirbekk.
Does Childbearing Affect Cognitive Health in Later Life? Evidence From an Instrumental Variable Approach.
Demography, 2022
DOI: 10.1215/00703370-9930490

More Quick Hits

How Variability Increases Learning

How Variability Increases Learning

. . .

 

This content is only for Premium Brains - please subscribe to access this. All subscriptions come with a free trial.
Register for free to receive access to "Healthy Brains" and other selected articles.
Subscribe to Premium Brain (monthly or annual) to access all articles and access the download page.

Subscribe now

 

leadership brain magazine

How Sleep Helps Your Brain Manage Fear

How Sleep Helps Your Brain Manage Fear

Quick Hits
Daily brief research updates from the cognitive sciences

sleep brain health

Sleeping well is essential to brain health

Sleep on i” is common advice for many reasons. Often to consolidate thoughts and help boost creativity. This is a well-known effect. We also know that sleep is the time that helps to detoxify and grow the brain and body, and I have reported on some of these effects in different posts. But this latest research, from the University of Bern, here in Switzerland, supports another hypothesis of sleep — namely that it helps with your emotions.

That sleep, particularly REM sleep (REM sleep is the light sleep phases often associated with dreaming), helps consolidate emotions has been long known. But these researchers found out precisely how this happens in brain cells themselves and this is pretty cool, I have to say.

So, what did they find?

First off, these researchers conditioned mice to two signals. One a fear signal and second, a safety signal. These are the two obvious big emotions in terms of survival and something that is present in all species of animal. They were then able to precisely track these signals in the mice.

What they then found during sleep was astonishing. They found that there was decoupling within neurons to these signals. Specifically, the cell body seemed to be deactivated whereas the dendrites the connecting arms of the neurons activated and processing the emotion. This, the researchers note translates into preferential processing in sleep of safety signals and avoidance of overgeneralising fear emotions which can become generalised anxiety — and they suspect potentially lead to anxiety disorders.

So, the brain needs sleep to process emotions and recorrect emotional signalling but specifically the decoupling of brain cells enables the processing of fear without generalising this. Clever old brain cells.

So, another, another, very good reason to get a good night’s sleep. If you are wondering how much — this latest research here answers that.

Andy Habermacher

Andy Habermacher

Andy is author of leading brains Review, Neuroleadership, and multiple other books. He has been intensively involved in writing and research into neuroleadership and is considered one of Europe’s leading experts. He is also a well-known public speaker speaking on the brain and human behaviour.

Andy is also a masters athlete (middle distance running) and competes regularly at international competitions (and holds a few national records in his age category).

twitter / LinkedIn

Reference

Mattia Aime, Niccolò Calcini, Micaela Borsa, Tiago Campelo, Thomas Rusterholz, Andrea Sattin, Tommaso Fellin, Antoine Adamantidis.
Paradoxical somatodendritic decoupling supports cortical plasticity during REM sleep.
Science, 2022; 376 (6594): 724
DOI: 10.1126/science.abk2734

More Quick Hits

Video games can boost children’s intelligence

Video games can boost children’s intelligence

Quick Hits
Daily brief research updates from the cognitive sciences

gaming children intelligence

 

Well, this is not the answer many of us would expect, and it goes against other logic of spending more time doing other things such as reading or socialising with friends (which the science also says is extremely beneficial to developing brains).

So, what did these researchers from the Karolinska institute in Sweden find and how did they find this?

The researchers around Bruno Sauce surveyed 5’000 children in the USA between the ages of nine and ten. They conducted a battery of tests, including cognitive and intelligence tests. Their parents were also asked about the children’s screen time and how much they spent on various activities. There was then a follow up 2 years later.

They found that those that spent most time on video games increased their intelligence by, on average, 2.5 points (or about 2.5%). There was no significant effect observed for TV or social media usage (positive or negative). In case you’re interested the average for these 5’000 children was 2.5 hrs of TV per day, half an hour on social media and an hour playing video games. I imagine there was a large variation in that. Remember these were between the ages of nine and ten at the outset of the study.

So, what to make of this?

Firstly, on closer inspection that playing video games increases intelligence shouldn’t be such a large surprise. Playing games requires multiple cognitive resources and is an active activity, in contrast to the passive activity of watching TV, with social media somewhere in the middle.

Secondly, it also shows that intelligence is a more a fluid concept than many think. With active use of cognitive resources intelligence does and will increase – this is an important, if not the most important, take away from this study.

However, a big caveat is they didn’t measure other aspects which we know will be important such as wellbeing, physical activity, or school performance, all of which can be critical factors in a child’s life and healthy development.

Of note also is that the hours of engagement with video games seem reasonable.

So, allowing kids to play video games, if they so wish, for reasonable amounts of time, is in fact a good thing and has benefits over simply watching TV. It isn’t a free card either – other things do count such as physical activity and nutrition which I have also written about multiple times here.

It might also do some of us oldies a bit of good as well!

Andy Habermacher

Andy Habermacher

Andy is author of leading brains Review, Neuroleadership, and multiple other books. He has been intensively involved in writing and research into neuroleadership and is considered one of Europe’s leading experts. He is also a well-known public speaker speaking on the brain and human behaviour.

Andy is also a masters athlete (middle distance running) and competes regularly at international competitions (and holds a few national records in his age category).

twitter / LinkedIn

Reference

Bruno Sauce, Magnus Liebherr, Nicholas Judd, Torkel Klingberg.
The impact of digital media on children’s intelligence while controlling for genetic differences in cognition and socioeconomic background.
Scientific Reports, 2022; 12 (1)
DOI: 10.1038/s41598-022-11341-2

More Quick Hits